La Liga leaders Villarreal’s unbeaten start to the season came to an end as Levante claimed their first win of the campaign with a 1-0 victory on Sunday.
Villarreal were reduced to 10 men on 35 minutes when Bojan Jokic saw a straight red card for a high challenge on Ivan Lopez.
The visitors held out until seven minutes from time when Brazilian striker Deyverson converted Nabil El Ghilas’s cross to take Levante off the foot of the table.
Defeat for Villarreal means Real Madrid can move to the top of the table if they beat Atletico Madrid later on Sunday.
Elsewhere, the pressure on Valencia boss Nuno Espirito Santo was increased as his side blew a 1-0 lead to lose 3-1 at Athletic Bilbao.
Dani Parejo put the visitors in front at San Mames as they looked to build on 1-0 victories against Granada and Lyon in the past week.
However, Athletic came roaring back to secure just their second win of the season thanks to goals from Aymeric Laporte, Markel Susaeta and Aritz Aduriz.
Real Betis moved up to eighth as goals in either half from Heiko Westermann and Ruben Castro handed them a 2-0 win at Rayo Vallecano.