Last year’s beaten finalists Liverpool were paired with Neymar’s Paris Saint-Germain in Thursday’s draw for the group stage of the Champions League.
The Premier League leaders also face last year’s Serie A runners up Napoli and former European champions Red Star Belgrade.
English champions Manchester City were placed in Group F with Shakhtar Donetsk, Lyon and Hoffenheim.
Tottenham, who last year topped a group containing reigning and eventual champions Real Madrid, will face three former European champions: Barcelona, PSV Eindhoven and Inter Milan.
Group A: Atletico Madrid (ESP), Borussia Dortmund (GER), Monaco (FRA), Club Brugge (BEL)
Group B: Barcelona (ESP), Tottenham Hotspur (ENG), PSV Eindhoven (NED), Inter (ITA)
Group C: Paris Saint-Germain (FRA), Napoli (ITA), Liverpool (ENG), Red Star Belgrade (SRB)
Group D: Lokomotiv Moscow (RUS), FC Porto (POR), Schalke 04 (GER), Galatasaray (TUR)
Group E: Bayern Munich (GER), Benfica (POR), Ajax (NED), AEK Athens (GRE)
Group F: Manchester City (ENG), Shakhtar Donetsk (UKR), Lyon (FRA), Hoffenheim (GER)
Group G: Real Madrid (ESP), Roma (ITA), CSKA Moscow (RUS), Viktoria Plzen (CZE)
Group H: Juventus (ITA), Manchester United (ENG), Valencia (ESP), Young Boys (SUI)
– First round of matches on September 18 and 19