British number one Heather Watson will attempt to win her first US Open match when she plays American Lauren Davis on Monday.
The pair will meet in the opening match on court 17 at 16:00 BST as the final Grand Slam of 2015 gets under way.
Watson, ranked 61st, hopes to claim her first win on her fifth visit to Flushing Meadows.
Serena Williams, Novak Djokovic and Rafael Nadal are also in action on day one.
Britons Andy Murray, Aljaz Bedene, James Ward, Jo Konta and Laura Robson begin their campaigns on Tuesday.
Source: bbc sport